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KMID : 0363220080460050715
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Korean Journal of Dermatology
2008 Volume.46 No. 5 p.715 ~ p.717
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Warfarin-induced Leukocytoclastic Vasculitis
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Kim Jae-Hwan
Jeong Se-Yeong
Seo Soo-Hong
Son Sang-Wook
Kim Il-Hwan
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Abstract
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Leukocytoclastic vasculitis is a small vessel inflammatory disease, mediated mostly by deposition of immune complexes. Medications cause 10∼24% of cases of leukocytoclastic vasculitic skin lesions, but warfarin has rarely been implicated. We report a case of warfarin-induced leukocytoclastic vasculitis in a 72-year-old woman which developed 45 days after warfarin medication. Palpable purpura, hemorrhagic vesicles, and ulcers developed on both lower legs. A skin biopsy showed characteristic features of leukocytoclastic vasculitis. Warfarin was replaced by clopidogrel, and the skin lesions gradually disappeared after 3 weeks. (Korean J Dermatol 2008;46(5):715∼717)
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KEYWORD
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Leukocytoclastic vasculitis, Warfarin
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